Guwahati | Off-spinner Simon Harmer picked a six-wicket haul as South Africa defeated India by 408 runs in the second Test to complete a 2-0 series whitewash here on Wednesday.

The loss marks another embarrassing chapter in India's Test history as it was their biggest loss in terms of runs. It was South Africa's first series win in India in 25 years.

Chasing an improbable 549-run target, Ravindra Jadeja waged a lone battle, scoring an 87-ball 54.

Harmer, who recorded career-best figures of 6/37, ended with a match haul of nine wickets.

The tourists outplayed India in all three departments, with Aiden Markram (9) setting the record for most catches in a Test match, overtaking Ajinkya Rahane's eight claimed in 2015.

Sai Sudharsan's excruciating 138-ball stay came to an end as Senuran Muthusamy had him caught by Markram soon after the second session began as India failed to reach even 150.

Brief Scores:

South Africa: 489 & 260 for 5 declared

India: 201 & 140 all out in 63.4 overs (Ravindra Jadeja 54, Washington Sundar 16, Simon Harmer 6/37).

Scoreboard on the final day of the second Test between India and South Africa here on Wednesday.

South Africa 1st innings: 489

India 1st Innings: 201

South Africa 2nd Innings: 260-5d

India 2nd Innings:

Yashasvi Jaiswal c Verreynne b Jansen 13

KL Rahul b Harmer 6

Sai Sudharsan batting 14

Kuldeep Yadav b Harmer 5

Dhruv Jurel c Markram b Harmer 2

Rishabh Pant c Markram b Harmer 13

Ravindra Jadeja st Verreynne b Maharaj 54

Washington Sundar c Markram b Harmer 16

Nitish Kumar Reddy c Verreynne b Harmer 0

Jasprit Bumrah not out 1

Mohammed Siraj c Marco Jansen b Maharaj 0

Extras: (B-5, LB-9, NB-2) 16

Total: (all out in 63.5 overs) 140

Fall of wickets: 1-17, 2-21,3-40, 4-42, 5-58, 6-95, 7-130, 8-138, 9-140, 10-140.

Bowling: Marco Jansen 15-7-23-1, Wiaan Mulder 4-1-6-0, Simon Harmer 23-6-37-6, Keshav Maharaj 12.5-1-37-2, Aiden Markram 2-0-2-0, Senuran Muthusamy 7-1-21-1